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JARID1C
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Belongs to the JARID1 histone demethylase family. Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: X F3|X 68.46 cM |
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Cellular Component:
chromatin; cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
dioxygenase activity; DNA binding; histone H3K4 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; identical protein binding; metal ion binding; oxidoreductase activity; RNA polymerase II-specific DNA-binding transcription factor binding; zinc ion binding
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Biological Process:
chromatin organization; chromatin remodeling; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of DNA-templated transcription; rhythmic process
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Reference #:
P41230
(UniProtKB)
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Alt. Names/Synonyms: [histone H3]-trimethyl-L-lysine(4) demethylase 5C; D930009K15Rik; Histone demethylase JARID1C; Jari; Jarid1c; jumonji, AT rich interactive domain 1C (Rbp2 like); Jumonji/ARID domain-containing protein 1C; Kdm5c; Kiaa0234; lysine (K)-specific demethylase 5C; Lysine-specific demethylase 5C; mKIAA0234; OTTMUSP00000018727; Protein SmcX; Protein Xe169; selected mouse cDNA on the X; Smc; Smcx; Xe169
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Gene Symbols: Kdm5c
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Molecular weight:
175,313 Da
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Basal Isoelectric point:
5.33
Predict pI for various phosphorylation states
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CST Pathways:
Histone Methylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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