5-HT(2A) G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. Belongs to the G-protein coupled receptor 1 family. Detected in brain cortex (at protein level). Detected in blood platelets. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 14 D3|14 39.37 cM
Cellular Component:  cell body fiber; cell projection; cytoplasmic vesicle; dendrite; dendritic shaft; G protein-coupled serotonin receptor complex; glutamatergic synapse; membrane; neuronal cell body; plasma membrane; postsynaptic membrane; presynaptic membrane; synapse
Molecular Function:  1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; G protein-coupled receptor activity; G protein-coupled serotonin receptor activity; Gq/11-coupled serotonin receptor activity; identical protein binding; neurotransmitter receptor activity; protein tyrosine kinase activator activity; protein-containing complex binding; serotonin binding
Biological Process:  activation of phospholipase C activity; artery smooth muscle contraction; behavior; behavioral response to cocaine; chemical synaptic transmission; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G protein-coupled serotonin receptor signaling pathway; glycolytic process; intracellular calcium ion homeostasis; memory; negative regulation of potassium ion transport; negative regulation of synaptic transmission, glutamatergic; peptidyl-tyrosine phosphorylation; phosphatidylinositol 3-kinase signaling; phospholipase C-activating G protein-coupled receptor signaling pathway; phospholipase C-activating serotonin receptor signaling pathway; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fat cell differentiation; positive regulation of glycolytic process; positive regulation of MAP kinase activity; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of vasoconstriction; presynaptic modulation of chemical synaptic transmission; protein localization to cytoskeleton; regulation of dopamine secretion; release of sequestered calcium ion into cytosol; response to xenobiotic stimulus; signal transduction; temperature homeostasis; urinary bladder smooth muscle contraction
Reference #:  P35363 (UniProtKB)
Alt. Names/Synonyms: 5-HT(2A); 5-HT-2; 5-HT-2A; 5-HT2A receptor; 5-hydroxytryptamine (serotonin) receptor 2A; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; 5HT2A; E030013E04; Htr; Htr-; Htr-2; Htr2; Htr2a; MGC124301; MGC124302; Serotonin receptor 2A
Gene Symbols: Htr2a
Molecular weight: 52,842 Da
Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein