EFTUD2 Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of mouse Ortholog: 11|11 E1
Cellular Component:  Cajal body; catalytic step 2 spliceosome; cytosol; intracellular membrane-bounded organelle; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex
Molecular Function:  GTP binding; GTPase activity; nucleotide binding; protein binding; U5 snRNA binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; RNA splicing
Reference #:  O08810 (UniProtKB)
Alt. Names/Synonyms: 116 kDa U5 small nuclear ribonucleoprotein component; 116kD; 116kDa; Eftud2; elongation factor Tu GTP binding domain containing 2; Elongation factor Tu GTP-binding domain-containing protein 2; Snr; Snrp116; U5 small nuclear ribonucleoprotein 116 kDa; U5 snRNP-specific protein, 116 kDa; U5-116 kDa; U5-116kD; U5S1
Gene Symbols: Eftud2
Molecular weight: 109,361 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein