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ZNF516
a transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress. Belongs to the krueppel C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; Transcription regulation |
| Chromosomal Location of Human Ortholog: 18|18 E3 |
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Cellular Component:
nucleus
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Molecular Function:
activating transcription factor binding; DNA binding; metal ion binding; nucleic acid binding; proximal promoter sequence-specific DNA binding
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Biological Process:
adipose tissue development; brown fat cell differentiation; positive regulation of cold-induced thermogenesis; positive regulation of transcription, DNA-templated; response to cold
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Reference #:
Q7TSH3
(UniProtKB)
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Alt. Names/Synonyms: C330029B10Rik; D230016L03; Kiaa0222; mKIAA0222; Zfp2; Zfp26l; Zfp516; zinc finger protein 26-like; Zinc finger protein 516; ZN516; Znf516
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Gene Symbols: Znf516
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Molecular weight:
124,788 Da
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Basal Isoelectric point:
8.84
Predict pI for various phosphorylation states
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