ZNF516 a transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress. Belongs to the krueppel C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription regulation
Chromosomal Location of Human Ortholog: 18|18 E3
Cellular Component:  nucleus
Molecular Function:  activating transcription factor binding; DNA binding; metal ion binding; nucleic acid binding; proximal promoter sequence-specific DNA binding
Biological Process:  adipose tissue development; brown fat cell differentiation; positive regulation of cold-induced thermogenesis; positive regulation of transcription, DNA-templated; response to cold
Reference #:  Q7TSH3 (UniProtKB)
Alt. Names/Synonyms: C330029B10Rik; D230016L03; Kiaa0222; mKIAA0222; Zfp2; Zfp26l; Zfp516; zinc finger protein 26-like; Zinc finger protein 516; ZN516; Znf516
Gene Symbols: Znf516
Molecular weight: 124,788 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene