CYP2C9 A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. Belongs to the cytochrome P450 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of mouse Ortholog: 19|19 C3
Cellular Component:  cytoplasm; endoplasmic reticulum; intracellular membrane-bounded organelle; membrane
Molecular Function:  arachidonic acid epoxygenase activity; aromatase activity; heme binding; iron ion binding; linoleic acid epoxygenase activity; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity
Biological Process:  arachidonic acid metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; linoleic acid metabolic process; organic acid metabolic process; oxidation-reduction process; xenobiotic metabolic process
Reference #:  Q9D816 (UniProtKB)
Alt. Names/Synonyms: 2010318C06Rik; CP255; Cyp2c-55; Cyp2c55; CYP2C9; CYPIIC55; Cytochrome P450 2C55; cytochrome P450, 2c55; cytochrome P450, family 2, subfamily c, polypeptide 55; OTTMUSP00000027819
Gene Symbols: Cyp2c55
Molecular weight: 56,096 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
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CYP2C9

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene