SMS2 Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. Belongs to the sphingomyelin synthase family. Brain, heart, kidney, liver, muscle and stomach. Also expressed in a number of cell lines such as carcinoma HeLa cells, hepatoma Hep-G2 cells, and colon carcinoma Caco-2 cells. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of mouse Ortholog: 3|3 G3
Cellular Component:  Golgi apparatus; integral component of endoplasmic reticulum membrane; integral component of Golgi membrane; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  ceramide cholinephosphotransferase activity; ceramide phosphoethanolamine synthase activity; kinase activity; sphingomyelin synthase activity; transferase activity
Biological Process:  ceramide biosynthetic process; ceramide phosphoethanolamine biosynthetic process; lipid metabolic process; phosphorylation; sphingolipid biosynthetic process; sphingolipid metabolic process; sphingomyelin biosynthetic process
Reference #:  Q9D4B1 (UniProtKB)
Alt. Names/Synonyms: 4933405A16Rik; 5133401H06Rik; AI854299; OTTMUSP00000025844; Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sgms2; SMS2; Sphingomyelin synthase 2
Gene Symbols: Sgms2
Molecular weight: 42,248 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene