RED1 Editing of the messenger RNAs for glutamate receptor (GluR) subunits by site-selective adenosine deamination. Edits both the GluR-B Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.4.37; Hydrolase; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component:  cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus
Molecular Function:  adenosine deaminase activity; double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; hydrolase activity; metal ion binding; protein homodimerization activity; RNA binding; tRNA-specific adenosine deaminase activity
Biological Process:  adenosine to inosine editing; base conversion or substitution editing; facial nerve morphogenesis; hypoglossal nerve morphogenesis; innervation; motor behavior; motor neuron apoptotic process; mRNA modification; mRNA processing; multicellular organism growth; muscle tissue morphogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase activity by regulation of protein phosphorylation; neuromuscular process controlling posture; neuromuscular synaptic transmission; positive regulation of mRNA processing; positive regulation of viral genome replication; regulation of cell cycle; RNA processing; spinal cord ventral commissure morphogenesis
Reference #:  Q91ZS8 (UniProtKB)
Alt. Names/Synonyms: 1700057H01Rik; Adar2; Adarb1; adenosine deaminase, RNA-specific, B1; AW124433; AW558573; BB220382; D10Bwg0447e; Double-stranded RNA-specific editase 1; dsRNA adenosine deaminase; OTTMUSP00000022332; OTTMUSP00000022333; OTTMUSP00000022334; OTTMUSP00000022335; OTTMUSP00000022336; OTTMUSP00000022337; Red1; RNA-editing deaminase 1; RNA-editing enzyme 1
Gene Symbols: Adarb1
Molecular weight: 78,001 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Select Structure to View Below

RED1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene