MEKK3 Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; MEKK2 subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Chromosomal Location of mouse Ortholog: 11|11 E1
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  blood vessel development; intracellular signal transduction; negative regulation of cellular senescence; phosphorylation; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell proliferation in bone marrow; positive regulation of p38MAPK cascade; protein autophosphorylation; protein phosphorylation
Reference #:  Q61084 (UniProtKB)
Alt. Names/Synonyms: AW548911; KIAA4031; M3K3; Map3k3; MAPK/ERK kinase kinase 3; MAPKK; MAPKKK3; MEK kinase 3; MEKK 3; Mekk3; mitogen activated protein kinase kinase kinase 3; Mitogen-activated protein kinase kinase kinase 3; mKIAA4031; OTTMUSP00000002980
Gene Symbols: Map3k3
Molecular weight: 70,776 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein