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BIRC4BP
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level). 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Tumor suppressor |
| Chromosomal Location of mouse Ortholog: 11|11 B4 |
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Cellular Component:
cytoplasm; mitochondrion; nucleoplasm; nucleus
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Molecular Function:
metal ion binding; molecular sequestering activity
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Biological Process:
apoptotic process; negative regulation of protein-containing complex assembly; negative regulation of type I interferon production; response to interferon-beta
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Reference #:
Q5NBU8
(UniProtKB)
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Alt. Names/Synonyms: BIRC4-binding protein; Birc4bp; F-box protein 39; Fbox39; Fbxo39; novel TRAF-type zinc finger protein; OTTMUSP00000006400; Xaf1; XIAP associated factor 1; XIAP-associated factor 1; Xiapaf1
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Gene Symbols: Xaf1
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Molecular weight:
31,117 Da
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Basal Isoelectric point:
8.92
Predict pI for various phosphorylation states
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