PNN Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. Belongs to the pinin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 12 C1|12 26.0 cM
Cellular Component:  catalytic step 2 spliceosome; cell junction; cytoplasm; desmosome; exon-exon junction complex; nuclear speck; nucleus; spliceosomal complex
Molecular Function:  DNA binding
Biological Process:  cell-cell adhesion; mRNA processing; RNA splicing
Reference #:  O35691 (UniProtKB)
Alt. Names/Synonyms: AU045199; D12Ertd512e; Pinin; Pnn
Gene Symbols: Pnn
Molecular weight: 82,436 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
Select Structure to View Below

PNN

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene