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Securin
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family. Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 11|11 B1.1 |
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Cellular Component:
cytoplasm; cytosol; nucleus
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Molecular Function:
cysteine-type endopeptidase inhibitor activity; heat shock protein binding; molecular function activator activity; ribosome binding; SH3 domain binding
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Biological Process:
cell cycle; cell division; chromosome organization; chromosome segregation; DNA damage response; DNA repair; homologous chromosome segregation; mitotic sister chromatid cohesion; negative regulation of cell population proliferation; regulation of cell growth
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Reference #:
Q9CQJ7
(UniProtKB)
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Alt. Names/Synonyms: AW555095; C87862; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1; Pituitary tumor-transforming gene 1 protein; PTT; Pttg; Pttg1; Pttg3; sec; Securin
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Gene Symbols: Pttg1
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Molecular weight:
21,725 Da
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Basal Isoelectric point:
6.17
Predict pI for various phosphorylation states
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