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CK1A
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CK1 group; CK1 family; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of Human Ortholog: 18|18 E1 |
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Cellular Component:
beta-catenin destruction complex; cell projection; centrosome; chromosome; chromosome, centromeric region; ciliary basal body; cytoplasm; cytoskeleton; cytosol; kinetochore; nuclear speck; nucleus; ribonucleoprotein complex
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Molecular Function:
ATP binding; kinase activity; magnesium ion binding; nucleotide binding; peptide binding; phosphoprotein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cell cycle; cell division; cell morphogenesis; Golgi organization; intermediate filament cytoskeleton organization; negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein phosphorylation; regulation of GTP binding; Wnt signaling pathway
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Reference #:
Q8BK63
(UniProtKB)
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Alt. Names/Synonyms: 2610208K14Rik; 4632404G05Rik; 5430427P18Rik; casein kinase 1, alpha 1; casein kinase I; Casein kinase I isoform alpha; casein kinase I-alpha; CK1; CK1A; CKI-alpha; Csnk1a; Csnk1a1; KC1A; MGC29354; MGC30571
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Gene Symbols: Csnk1a1
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Molecular weight:
38,915 Da
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Basal Isoelectric point:
9.59
Predict pI for various phosphorylation states
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CST Pathways:
Hedgehog Signaling
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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