CK1A Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CK1 group; CK1 family; EC; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 18|18 E1
Cellular Component:  beta-catenin destruction complex; cell projection; centrosome; chromosome; chromosome, centromeric region; ciliary basal body; cilium; cytoplasm; cytoskeleton; cytosol; keratin filament; kinetochore; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck; nucleus; ribonucleoprotein complex; spindle
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; nucleotide binding; peptide binding; phosphoprotein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell division; cell morphogenesis; Golgi organization; intermediate filament cytoskeleton organization; negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein phosphorylation; regulation of GTP binding; signal transduction; Wnt signaling pathway
Reference #:  Q8BK63 (UniProtKB)
Alt. Names/Synonyms: 2610208K14Rik; 4632404G05Rik; 5430427P18Rik; casein kinase 1, alpha 1; casein kinase I; Casein kinase I isoform alpha; casein kinase I-alpha; CK1; CK1A; CKI-alpha; Csnk1a; Csnk1a1; KC1A; MGC29354; MGC30571
Gene Symbols: Csnk1a1
Molecular weight: 38,915 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene