Symplekin Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. Belongs to the Symplekin family. In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts, lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks, Purkinje fiber cells of the heart and lymph node. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; RNA processing
Chromosomal Location of mouse Ortholog: 7|7 A3
Cellular Component:  bicellular tight junction; cell junction; cytoplasm; cytoskeleton; cytosol; membrane; nuclear body; nuclear stress granule; nucleoplasm; nucleus; plasma membrane
Biological Process:  cell adhesion; mRNA polyadenylation; mRNA processing; negative regulation of protein binding; positive regulation of protein dephosphorylation
Reference #:  Q80X82 (UniProtKB)
Alt. Names/Synonyms: 1500016F02Rik; 4632415H16Rik; AA125406; AI449890; OTTMUSP00000025980; SPK; SYM; Sympk; Symplekin
Gene Symbols: Sympk
Molecular weight: 142,620 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Symplekin

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein