Elf-2 Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. Isoform 2 may function in repression of RUNX1-mediated transactivation. Belongs to the ETS family. Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary. Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain and peripheral blood lymphocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 3|3 C
Cellular Component:  cytosol; nuclear body; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; sequence-specific DNA binding
Biological Process:  cell differentiation; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q9JHC9 (UniProtKB)
Alt. Names/Synonyms: 2610036A20Rik; A230104O07Rik; AW111824; BB183398; E74-like factor 2; Elf2; ets domain transcription factor; ets family transcription factor ELF2A2; ETS-related transcription factor Elf-2; EU32; MGC102660; Nerf; NERF-1A; NERF-1B; NERF-2; New ETS-related factor; OTTMUSP00000023461
Gene Symbols: Elf2
Molecular weight: 63,203 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
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Elf-2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene