DSG2 Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. All of the tissues tested and carcinomas. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Cell adhesion; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 18 A2|18 11.42 cM
Cellular Component:  apical plasma membrane; cell junction; cell-cell junction; desmosome; integral component of membrane; intercalated disc; intracellular membrane-bounded organelle; lateral plasma membrane; membrane; plasma membrane
Molecular Function:  calcium ion binding; cell adhesion molecule binding; metal ion binding
Biological Process:  bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cell adhesion; cell-cell adhesion; desmosome organization; homophilic cell adhesion via plasma membrane adhesion molecules; Purkinje myocyte development; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential
Reference #:  O55111 (UniProtKB)
Alt. Names/Synonyms: AA408168; D18Ertd293; D18Ertd293e; desmoglein 2; Desmoglein-2; Dsg2
Gene Symbols: Dsg2
Molecular weight: 122,385 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene