PCIF1 may play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit (RNAP IIO). Interacts with the phosphorylated CTD of RNAPII via its WW domain. Bnds to the hyperphosphorylated RNAP IIO in vitro and in vivo. Note: This description may include information from UniProtKB.
Protein type: RNA processing
Chromosomal Location of Human Ortholog: 2|2 H3
Cellular Component:  intercellular bridge; microtubule cytoskeleton; nucleoplasm; nucleus
Molecular Function:  methyltransferase activity; mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; RNA polymerase II C-terminal domain binding; S-adenosyl-L-methionine binding; transferase activity
Biological Process:  methylation; mRNA methylation; negative regulation of phosphatase activity; positive regulation of translation
Reference #:  P59114 (UniProtKB)
Alt. Names/Synonyms: 2310022K11Rik; C20orf67; F730014I05Rik; MGC25976; OTTMUSP00000001063; Pcif1; PDX1 C-terminal inhibiting factor 1; phosphorylated CTD interacting factor PCIF1; Phosphorylated CTD-interacting factor 1
Gene Symbols: Pcif1
Molecular weight: 80,504 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
Select Structure to View Below

PCIF1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene