FCGR2B Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Oncoprotein
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component:  cell body; dendritic spine; external side of plasma membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  amyloid-beta binding; IgG binding; low-affinity IgG receptor activity; protein binding; protein-containing complex binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; cellular response to amyloid-beta; cellular response to molecule of bacterial origin; cerebellum development; defense response; Fc-gamma receptor signaling pathway involved in phagocytosis; follicular B cell differentiation; follicular dendritic cell activation; immune complex clearance by monocytes and macrophages; immune response; immunoglobulin mediated immune response; inflammatory response; mature B cell differentiation involved in immune response; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of antibody-dependent cellular cytotoxicity; negative regulation of B cell activation; negative regulation of B cell proliferation; negative regulation of B cell receptor signaling pathway; negative regulation of cytokine secretion; negative regulation of cytotoxic T cell degranulation; negative regulation of dendritic cell antigen processing and presentation; negative regulation of dendritic cell differentiation; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of immune response; negative regulation of immunoglobulin production; negative regulation of interleukin-10 production; negative regulation of macrophage activation; negative regulation of neutrophil activation; negative regulation of phagocytosis; negative regulation of type I hypersensitivity; phagocytosis, engulfment; positive regulation of humoral immune response; positive regulation of JNK cascade; positive regulation of neuron death; positive regulation of phagocytosis; positive regulation of response to endoplasmic reticulum stress; receptor-mediated endocytosis; regulation of adaptive immune response; regulation of B cell antigen processing and presentation; regulation of dendritic spine maintenance; regulation of immune complex clearance by monocytes and macrophages; regulation of immune response; regulation of innate immune response; regulation of signaling receptor activity; response to bacterium; signal transduction; viral process
Disease: Malaria, Susceptibility To; Systemic Lupus Erythematosus
Reference #:  P31994 (UniProtKB)
Alt. Names/Synonyms: CD32; CD32B; CDw32; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma RIIb; Fc-gamma RII-b; Fc-gamma-RIIb; FCG2; FCG2B; FCGR2; FCGR2B; FcRII-b; IGFR2; IgG Fc receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-b
Gene Symbols: FCGR2B
Molecular weight: 34,044 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Select Structure to View Below

FCGR2B

Protein Structure Not Found.


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