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MLK4
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group |
| Chromosomal Location of mouse Ortholog: 8|8 E2 |
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Cellular Component:
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Molecular Function:
ATP binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
phosphorylation; protein phosphorylation
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Reference #:
Q8VDG6
(UniProtKB)
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Alt. Names/Synonyms: Kiaa1804; M3K21; M3KL4; Map3k21; MGC27778; Mitogen-activated protein kinase kinase kinase; Mitogen-activated protein kinase kinase kinase 21; Mitogen-activated protein kinase kinase kinase MLK4; Mixed lineage kinase 4; mKIAA1804; Mlk4
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Gene Symbols: Map3k21
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Molecular weight:
110,112 Da
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Basal Isoelectric point:
8.54
Predict pI for various phosphorylation states
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CST Pathways:
SAPK/JNK Signaling Cascades
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