RRP4 Non-catalytic component of the RNA exosome complex which has 3'- Belongs to the RRP4 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease
Chromosomal Location of mouse Ortholog: 2|2 B
Cellular Component:  cytoplasm; cytoplasmic exosome (RNase complex); exosome (RNase complex); nuclear exosome (RNase complex); nucleolus; nucleus
Molecular Function:  RNA binding
Biological Process:  CUT catabolic process; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nuclear polyadenylation-dependent rRNA catabolic process; nuclear polyadenylation-dependent tRNA catabolic process; nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; polyadenylation-dependent snoRNA 3'-end processing; positive regulation of cell growth; rRNA processing; U4 snRNA 3'-end processing
Reference #:  Q8VBV3 (UniProtKB)
Alt. Names/Synonyms: EXOS2; Exosc2; Exosome complex component RRP4; Exosome complex exonuclease RRP4; Exosome component 2; homolog of Yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease; MGC30456; OTTMUSP00000013001; Ribosomal RNA-processing protein 4; Rrp4
Gene Symbols: Exosc2
Molecular weight: 32,632 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
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RRP4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene