DGKA Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. Belongs to the eukaryotic diacylglycerol kinase family. Lymphocytes and oligodendroglial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10 D3|10 77.14 cM
Cellular Component:  cytosol; plasma membrane
Molecular Function:  ATP binding; calcium ion binding; diacylglycerol kinase activity; kinase activity; metal ion binding; NAD+ kinase activity; nucleotide binding; phospholipid binding; transferase activity
Biological Process:  diacylglycerol metabolic process; glycerolipid metabolic process; intracellular signal transduction; lipid phosphorylation; phosphatidic acid biosynthetic process; phosphorylation; protein kinase C-activating G protein-coupled receptor signaling pathway; signal transduction
Reference #:  O88673 (UniProtKB)
Alt. Names/Synonyms: 80 kDa diacylglycerol kinase; 80kDa; AW146112; DAG kinase alpha; Dagk; Dagk1; DGK-alpha; Dgka; Diacylglycerol kinase alpha; diacylglycerol kinase alpha Flt2-Pr2; diacylglycerol kinase, alpha; Diglyceride kinase alpha; truncated diacylglycerol kinase alpha Flt1-Pr1; truncated diacylglycerol kinase alpha Flt1-Pr2
Gene Symbols: Dgka
Molecular weight: 82,762 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
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DGKA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene