FBXO4 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 15|15 A1
Cellular Component:  cytoplasm; SCF ubiquitin ligase complex; ubiquitin ligase complex
Molecular Function:  protein binding; protein homodimerization activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  aging; cellular homeostasis; cellular response to ionizing radiation; common myeloid progenitor cell proliferation; negative regulation of fibroblast proliferation; negative regulation of protein localization to nucleus; positive regulation of protein polyubiquitination; positive regulation of protein ubiquitination; positive regulation of telomere maintenance via telomerase; posttranscriptional regulation of gene expression; protein destabilization; protein polyubiquitination; protein ubiquitination; regulation of DNA damage checkpoint; regulation of protein stability; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; telomere maintenance; ubiquitin-dependent protein catabolic process
Reference #:  Q8CHQ0 (UniProtKB)
Alt. Names/Synonyms: 1700096C12Rik; AI851261; AW494535; F-box only protein 4; F-box protein 4; Fbx4; Fbxo4
Gene Symbols: Fbxo4
Molecular weight: 43,777 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene