BCAP Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. Expressed in natural killer (NK) cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19|19 C3
Cellular Component:  cytoplasm; cytosol; membrane; plasma membrane
Molecular Function:  identical protein binding; phosphatidylinositol 3-kinase regulatory subunit binding; protein binding; signaling receptor binding
Biological Process:  negative regulation of toll-like receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of toll-like receptor signaling pathway; regulation of inflammatory response; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway
Reference #:  Q9EQ32 (UniProtKB)
Alt. Names/Synonyms: 1810044J04Rik; B cell phosphoinositide 3-kinase adaptor; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1; Bcap; Phosphoinositide 3-kinase adapter protein 1; phosphoinositide-3-kinase adaptor protein 1; Pik3ap1
Gene Symbols: Pik3ap1
Molecular weight: 90,928 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  PI3K/Akt Signaling
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BCAP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene