MORC2
Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing. Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AFX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA. Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9. Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation. Highly expressed in smooth muscle, pancreas and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding |
Chromosomal Location of mouse Ortholog: 11|11 A1 |
Cellular Component:
chromosome; cytoplasm; cytosol; heterochromatin; nuclear matrix; nucleoplasm; nucleus
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Molecular Function:
ATP binding; ATP hydrolysis activity; chromatin binding; histone binding; hydrolase activity; identical protein binding; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; zinc ion binding
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Biological Process:
chromatin remodeling; DNA damage response; negative regulation of gene expression, epigenetic; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; positive regulation of DNA methylation-dependent heterochromatin formation
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Reference #:
Q69ZX6
(UniProtKB)
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Alt. Names/Synonyms: 8430403M08Rik; ATPase MORC2A; Kiaa0852; microrchidia 2A; MOR2A; MORC family CW-type zinc finger protein 2A; MORC2; Morc2a; Zcwcc1; Zinc finger CW-type coiled-coil domain protein 1; zinc finger, CW-type with coiled-coil domain 1
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Gene Symbols: Morc2a
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Molecular weight:
117,330 Da
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Basal Isoelectric point:
8.54
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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