PACS-1 Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Belongs to the PACS family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  COPI-coated vesicle; Golgi apparatus; perinuclear region of cytoplasm
Molecular Function:  ion channel binding
Biological Process:  cellular protein localization; positive regulation of protein binding; protein localization to Golgi apparatus; protein localization to plasma membrane
Reference #:  Q8K212 (UniProtKB)
Alt. Names/Synonyms: AI325977; cytosolic sorting protein PACS-1; MGC37046; PACS-1; Pacs1; Phosphofurin acidic cluster sorting protein 1
Gene Symbols: Pacs1
Molecular weight: 104,829 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene