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PACS-1
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Belongs to the PACS family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 19|19 A |
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Cellular Component:
COPI-coated vesicle; Golgi apparatus; perinuclear region of cytoplasm
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Molecular Function:
protein binding; transmembrane transporter binding
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Biological Process:
lymphocyte homeostasis; positive regulation of protein binding; protein localization to Golgi apparatus; protein localization to plasma membrane
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Reference #:
Q8K212
(UniProtKB)
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Alt. Names/Synonyms: AI325977; cytosolic sorting protein PACS-1; MGC37046; PACS-1; Pacs1; Phosphofurin acidic cluster sorting protein 1
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Gene Symbols: Pacs1
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Molecular weight:
104,829 Da
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Basal Isoelectric point:
7.6
Predict pI for various phosphorylation states
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