UBXN1 Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1. Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B. Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Proteasome complex; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  cytoplasm; cytosol; dendrite; endoplasmic reticulum; neuronal cell body; nucleus; VCP-NPL4-UFD1 AAA ATPase complex
Molecular Function:  ATPase binding; K48-linked polyubiquitin modification-dependent protein binding; K6-linked polyubiquitin modification-dependent protein binding; polyubiquitin modification-dependent protein binding; proteasome regulatory particle binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process:  negative regulation of ERAD pathway; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein K48-linked deubiquitination; negative regulation of protein ubiquitination; negative regulation of ubiquitin-specific protease activity
Reference #:  Q922Y1 (UniProtKB)
Alt. Names/Synonyms: 2B28; 4930455J02Rik; D19Ertd721; D19Ertd721e; MGC6696; mY33K; Protein 2B28; Saks1; SAPK substrate protein 1; T25529; UBA/UBX 33.3 kDa protein; UBX domain protein 1; UBX domain-containing protein 1; Ubxn1
Gene Symbols: Ubxn1
Molecular weight: 33,573 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
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UBXN1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene