ERK4 Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. High expression in heart and brain. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC 2.7.11.24; ERK3 subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 18|18 E2
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; MAP kinase activity; nucleotide binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; intracellular signal transduction; phosphorylation; protein phosphorylation
Reference #:  Q6P5G0 (UniProtKB)
Alt. Names/Synonyms: A330097D03Rik; ERK-4; Erk3; Erk3-related; Erk4; Extracellular signal-regulated kinase 4; MAP kinase 4; MAPK 4; Mapk4; mitogen activated protein kinase 4; Mitogen-activated protein kinase 4; MK04; p63M; p63Mapk; Prkm4
Gene Symbols: Mapk4
Molecular weight: 65,574 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
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ERK4

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein