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NOT3
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. Belongs to the CNOT2/3/5 family. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
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| Chromosomal Location of Human Ortholog: 7|7 A1 |
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Cellular Component:
CCR4-NOT complex; CCR4-NOT core complex; cytoplasm; nucleus; P-body
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Molecular Function:
protein binding
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Biological Process:
gene silencing by RNA; multicellular organism development; negative regulation of translation; positive regulation of cold-induced thermogenesis; regulation of stem cell population maintenance; regulation of transcription, DNA-templated; regulation of translation; trophectodermal cell differentiation
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Reference #:
Q8K0V4
(UniProtKB)
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Alt. Names/Synonyms: A930039N10Rik; CCR4-associated factor 3; CCR4-NOT transcription complex subunit 3; CCR4-NOT transcription complex, subunit 3; Cnot3; MGC40675; Not3
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Gene Symbols: Cnot3
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Molecular weight:
81,946 Da
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Basal Isoelectric point:
5.83
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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