UFL1 E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling. May also play a role in nuclear receptor-mediated transcription through TRIP4 ufmylation. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress. Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition. Belongs to the UFL1 family. Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such Hep-G2, Hep 3B2.1-7, HLE and PLC. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Tumor suppressor
Chromosomal Location of mouse Ortholog: 4|4 A3
Cellular Component:  chromosome; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; neuron projection; nucleus; protein-containing complex; site of double-strand break
Molecular Function:  protein binding; protein kinase binding; transferase activity; UFM1 ligase activity; UFM1 transferase activity
Biological Process:  DNA damage checkpoint signaling; DNA damage response; DNA repair; erythrocyte differentiation; hematopoietic stem cell differentiation; negative regulation of apoptotic process; negative regulation of IRE1-mediated unfolded protein response; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein ubiquitination; positive regulation of autophagy; positive regulation of cell population proliferation; positive regulation of glial cell proliferation; positive regulation of protein binding; protein K69-linked ufmylation; protein ufmylation; regulation of gene expression; regulation of intracellular estrogen receptor signaling pathway; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of protein localization; response to endoplasmic reticulum stress; response to L-glutamate; reticulophagy
Reference #:  Q8CCJ3 (UniProtKB)
Alt. Names/Synonyms: 1810074P20Rik; AI429228; E3 UFM1-protein ligase 1; E3 UFM1-protein transferase 1; hypothetical protein LOC67490; Kiaa0776; Max; Maxer; mKIAA0776; Multiple alpha-helix protein located at ER; OTTMUSP00000005060; Rcad; Regulator of C53/LZAP and DDRGK1; RIKEN cDNA 1810074P20 gene; Ufl1; UFM1 specific ligase 1
Gene Symbols: Ufl1
Molecular weight: 89,520 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene