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NIPP-1
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha ( 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.4.-; Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Ribonuclease |
| Chromosomal Location of Human Ortholog: 4|4 D2.3 |
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Cellular Component:
nuclear speck; nucleoplasm; nucleus; spliceosomal complex
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Molecular Function:
DNA binding; mRNA binding; protein binding; protein phosphatase inhibitor activity; protein phosphatase regulator activity; protein serine/threonine phosphatase inhibitor activity; RNA binding
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Biological Process:
cell proliferation; mRNA processing; multicellular organism development; negative regulation of protein dephosphorylation; production of miRNAs involved in gene silencing by miRNA; RNA splicing
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Reference #:
Q8R3G1
(UniProtKB)
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Alt. Names/Synonyms: 6330548N22Rik; AU044684; MGC38560; NIPP-1; Nipp1; Nuclear inhibitor of protein phosphatase 1; OTTMUSP00000010611; PP1R8; Ppp1r8; Protein phosphatase 1 regulatory inhibitor subunit 8; protein phosphatase 1, regulatory (inhibitor) subunit 8
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Gene Symbols: Ppp1r8
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Molecular weight:
38,528 Da
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Basal Isoelectric point:
6.87
Predict pI for various phosphorylation states
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