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KIF26A
Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motor |
| Chromosomal Location of Human Ortholog: 12|12 F1 |
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Cellular Component:
cytoplasm; cytoskeleton; kinesin complex; microtubule
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Molecular Function:
ATP binding; microtubule binding; microtubule motor activity; nucleotide binding; protein binding
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Biological Process:
enteric nervous system development; negative regulation of signal transduction; regulation of cell growth by extracellular stimulus
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Reference #:
Q52KG5
(UniProtKB)
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Alt. Names/Synonyms: KI26A; Kiaa1236; Kif26a; kinesin family member 26A; Kinesin-like protein KIF26A; mKIAA1236; N-11 kinesin
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Gene Symbols: Kif26a
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Molecular weight:
196,313 Da
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Basal Isoelectric point:
9.01
Predict pI for various phosphorylation states
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