ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver. 4 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis
Chromosomal Location of Human Ortholog: 17q12
Cellular Component:  actin cytoskeleton; cytosol; fibrillar center
Molecular Function:  acetyl-CoA carboxylase activity; ATP binding; biotin carboxylase activity; identical protein binding; metal ion binding; protein binding
Biological Process:  acetyl-CoA metabolic process; carnitine shuttle; cellular response to prostaglandin E stimulus; fatty acid biosynthetic process; fatty-acyl-CoA biosynthetic process; lipid homeostasis; malonyl-CoA biosynthetic process; positive regulation of cellular metabolic process; protein homotetramerization; protein metabolic process; regulation of cholesterol biosynthetic process; tissue homeostasis
Disease: Acetyl-coa Carboxylase Deficiency
Reference #:  Q13085 (UniProtKB)
Alt. Names/Synonyms: ACAC; ACACA; ACACAD; ACC; ACC-alpha; ACC1; ACCA; Acetyl-CoA carboxylase 1; acetyl-CoA carboxylase alpha; acetyl-CoA carboxylase-alpha; acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase
Gene Symbols: ACACA
Molecular weight: 265,554 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein