ZHX3 Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. Belongs to the ZHX family. Widely expressed. High expression in kidney. Expressed during osteogenic differentiation. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 2|2 H2
Cellular Component:  cell cortex; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process:  cell differentiation; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of osteoblast differentiation; regulation of transcription by RNA polymerase II
Reference #:  Q8C0Q2 (UniProtKB)
Alt. Names/Synonyms: 1810059C13Rik; 4932418O04Rik; 9530010N21Rik; Kiaa0395; mKIAA0395; OTTMUSP00000001010; OTTMUSP00000001011; Tix; Tix1; triple homeobox 1; Triple homeobox protein 1; Zhx3; Zinc finger and homeodomain protein 3; zinc fingers and homeoboxes 3; Zinc fingers and homeoboxes protein 3
Gene Symbols: Zhx3
Molecular weight: 104,343 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein