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ZHX3
Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. Belongs to the ZHX family. Widely expressed. High expression in kidney. Expressed during osteogenic differentiation. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 2|2 H2 |
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Cellular Component:
cell cortex; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; metal ion binding; nucleic acid binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding; transcription corepressor activity
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Biological Process:
cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of osteoblast differentiation
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Reference #:
Q8C0Q2
(UniProtKB)
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Alt. Names/Synonyms: 1810059C13Rik; 4932418O04Rik; 9530010N21Rik; Kiaa0395; mKIAA0395; OTTMUSP00000001010; OTTMUSP00000001011; Tix; Tix1; triple homeobox 1; Triple homeobox protein 1; Zhx3; Zinc finger and homeodomain protein 3; zinc fingers and homeoboxes 3; Zinc fingers and homeoboxes protein 3
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Gene Symbols: Zhx3
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Molecular weight:
104,343 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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