|
ZHX1
Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. Belongs to the ZHX family. Ubiquitously expressed. Expressed in podocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 15|15 D1 |
|
Cellular Component:
nucleoplasm; nucleus
|
|
Molecular Function:
DNA binding; DNA-binding transcription factor activity; metal ion binding; nucleic acid binding; protein heterodimerization activity; transcription corepressor activity
|
|
Biological Process:
negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated
|
|
Reference #:
P70121
(UniProtKB)
|
|
Alt. Names/Synonyms: 3110006I21Rik; KIAA4149; mKIAA4149; Zhx1; zinc finger and homeodomain protein 1; zinc fingers and homeoboxes 1; Zinc fingers and homeoboxes protein 1
|
|
Gene Symbols: Zhx1
|
|
Molecular weight:
97,551 Da
|
|
Basal Isoelectric point:
5.72
Predict pI for various phosphorylation states
|
