ZHX1 Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. Belongs to the ZHX family. Ubiquitously expressed. Expressed in podocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 15|15 D1
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein heterodimerization activity
Biological Process:  negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
Reference #:  P70121 (UniProtKB)
Alt. Names/Synonyms: 3110006I21Rik; KIAA4149; mKIAA4149; Zhx1; zinc finger and homeodomain protein 1; zinc fingers and homeoboxes 1; Zinc fingers and homeoboxes protein 1
Gene Symbols: Zhx1
Molecular weight: 97,551 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein