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XRN2
Possesses 5'- Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; EC 3.1.13.-; Nucleolus; RNA processing; RNA-binding; Ribonuclease |
| Chromosomal Location of mouse Ortholog: 2|2 G2 |
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Cellular Component:
aggresome; nucleolus; nucleoplasm; nucleus
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Molecular Function:
3'-5'-RNA exonuclease activity; 5'-3' exonuclease activity; 5'-3' RNA exonuclease activity; DNA binding; exonuclease activity; hydrolase activity; identical protein binding; metal ion binding; nuclease activity; nucleic acid binding; protein binding; RNA binding; transcription termination site sequence-specific DNA binding
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Biological Process:
DNA recombination; DNA repair; DNA-templated transcription termination; microtubule-based process; mRNA processing; nuclear-transcribed mRNA catabolic process; nucleobase-containing compound metabolic process; RNA metabolic process; spermatogenesis; termination of RNA polymerase II transcription
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Reference #:
Q9DBR1
(UniProtKB)
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Alt. Names/Synonyms: 5'-3' exoribonuclease 2; Dhm1; OTTMUSP00000016705; Protein Dhm1; Xrn2
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Gene Symbols: Xrn2
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Molecular weight:
108,687 Da
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Basal Isoelectric point:
7.52
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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