XRN2 Possesses 5'- Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; EC 3.1.13.-; Nucleolus; RNA processing; RNA-binding; Ribonuclease
Chromosomal Location of Human Ortholog: 2|2 G2
Cellular Component:  aggresome; nucleolus; nucleus
Molecular Function:  3'-5'-exoribonuclease activity; 5'-3' exonuclease activity; 5'-3' exoribonuclease activity; DNA binding; exonuclease activity; hydrolase activity; metal ion binding; nuclease activity; nucleic acid binding; protein binding; transcription termination site sequence-specific DNA binding
Biological Process:  DNA catabolic process, exonucleolytic; DNA recombination; DNA repair; DNA-templated transcription, termination; microtubule-based process; mRNA processing; nucleobase-containing compound metabolic process; RNA metabolic process; spermatogenesis
Reference #:  Q9DBR1 (UniProtKB)
Alt. Names/Synonyms: 5'-3' exoribonuclease 2; Dhm1; OTTMUSP00000016705; Protein Dhm1; Xrn2
Gene Symbols: Xrn2
Molecular weight: 108,687 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene