WTAP Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. Belongs to the fl(2)d family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Spliceosome
Chromosomal Location of mouse Ortholog: 17|17 A1
Cellular Component:  cytoplasm; nuclear membrane; nuclear speck; nucleoplasm; nucleus; RNA N6-methyladenosine methyltransferase complex
Molecular Function:  identical protein binding; protein binding
Biological Process:  cell cycle; mRNA methylation; mRNA processing; multicellular organism development; regulation of alternative mRNA splicing, via spliceosome; RNA splicing
Reference #:  Q9ER69 (UniProtKB)
Alt. Names/Synonyms: 2810408K05Rik; 9430038B09Rik; Female-lethal(2)D homolog; FL2D; Pre-mRNA-splicing regulator WTAP; Wilms tumor 1-associating protein; Wilms tumour 1-associating protein; Wilms' tumour 1-associating protein; WT1-associated protein; Wtap
Gene Symbols: Wtap
Molecular weight: 44,177 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene