WTAP Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation. Belongs to the fl(2)d family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Spliceosome
Chromosomal Location of Human Ortholog: 17|17 A1
Cellular Component:  cytoplasm; nuclear membrane; nuclear speck; nucleoplasm; nucleus; RNA N6-methyladenosine methyltransferase complex
Molecular Function:  protein binding
Biological Process:  cell cycle; mRNA methylation; mRNA processing; multicellular organism development; regulation of alternative mRNA splicing, via spliceosome; RNA splicing
Reference #:  Q9ER69 (UniProtKB)
Alt. Names/Synonyms: 2810408K05Rik; 9430038B09Rik; Female-lethal(2)D homolog; FL2D; Pre-mRNA-splicing regulator WTAP; Wilms tumor 1-associating protein; Wilms' tumour 1-associating protein; WT1-associated protein; Wtap
Gene Symbols: Wtap
Molecular weight: 44,177 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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WTAP

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene