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WTAP
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. Belongs to the fl(2)d family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus; Spliceosome |
| Chromosomal Location of Human Ortholog: 17|17 A1 |
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Cellular Component:
cytoplasm; nuclear membrane; nuclear speck; nucleoplasm; nucleus; RNA N6-methyladenosine methyltransferase complex
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Molecular Function:
protein binding
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Biological Process:
cell cycle; mRNA methylation; mRNA processing; multicellular organism development; regulation of alternative mRNA splicing, via spliceosome; RNA splicing
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Reference #:
Q9ER69
(UniProtKB)
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Alt. Names/Synonyms: 2810408K05Rik; 9430038B09Rik; Female-lethal(2)D homolog; FL2D; Pre-mRNA-splicing regulator WTAP; Wilms tumor 1-associating protein; Wilms tumour 1-associating protein; Wilms' tumour 1-associating protein; WT1-associated protein; Wtap
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Gene Symbols: Wtap
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Molecular weight:
44,177 Da
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Basal Isoelectric point:
5.17
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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