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WDR45B
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2. In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway. Belongs to the WD repeat SVP1 family. Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of Human Ortholog: 11 E2|11 85.24 cM |
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Cellular Component:
cytosol; extrinsic component of membrane; lysosome; phagophore assembly site; phagophore assembly site membrane
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Molecular Function:
lipid binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding
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Biological Process:
autophagosome assembly; autophagy; autophagy of mitochondrion; cellular response to starvation; protein lipidation; protein localization to phagophore assembly site
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Reference #:
Q9CR39
(UniProtKB)
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Alt. Names/Synonyms: 0610008N23Rik; AA408735; D16Bwg0193e; OTTMUSP00000004824; WD repeat domain 45B; WD repeat domain phosphoinositide-interacting protein 3; WD repeat-containing protein 45-like; WD repeat-containing protein 45B; Wdr4; Wdr45 like; WDR45-like protein; WDR45B; Wdr45l; WIPI-3; Wipi3
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Gene Symbols: Wdr45l
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Molecular weight:
38,021 Da
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Basal Isoelectric point:
7.52
Predict pI for various phosphorylation states
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