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WBP2
Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; Nuclear receptor co-regulator |
| Chromosomal Location of Human Ortholog: 11|11 E2 |
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Cellular Component:
cytoplasm; nuclear chromatin; nucleus
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Molecular Function:
chromatin DNA binding; estrogen receptor binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription coactivator activity
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Biological Process:
cellular response to estrogen stimulus; establishment of protein localization; positive regulation of gene expression, epigenetic; positive regulation of histone H3-K14 acetylation; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; response to estrogen; response to progesterone
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Reference #:
P97765
(UniProtKB)
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Alt. Names/Synonyms: OTTMUSP00000003889; WBP-2; Wbp2; WW domain binding protein 2; WW domain-binding protein 2
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Gene Symbols: Wbp2
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Molecular weight:
28,032 Da
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Basal Isoelectric point:
5.94
Predict pI for various phosphorylation states
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