WBP2 Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 11|11 E2
Cellular Component:  cytoplasm; nuclear chromatin; nucleus
Molecular Function:  chromatin DNA binding; estrogen receptor binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription coactivator activity
Biological Process:  cellular response to estrogen stimulus; establishment of protein localization; positive regulation of gene expression, epigenetic; positive regulation of histone H3-K14 acetylation; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; response to estrogen; response to progesterone
Reference #:  P97765 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000003889; WBP-2; Wbp2; WW domain binding protein 2; WW domain-binding protein 2
Gene Symbols: Wbp2
Molecular weight: 28,032 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA