WBP2
Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Cell development/differentiation; Nuclear receptor co-regulator |
Chromosomal Location of mouse Ortholog: 11|11 E2 |
Cellular Component:
chromatin; cytoplasm; cytosol; nucleoplasm; nucleus
|
Molecular Function:
chromatin DNA binding; nuclear estrogen receptor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription coactivator activity
|
Biological Process:
cellular response to estrogen stimulus; establishment of protein localization to chromatin; positive regulation of DNA-templated transcription; positive regulation of histone H3-K14 acetylation; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; response to estrogen; response to progesterone; transcription initiation-coupled chromatin remodeling
|
Reference #:
P97765
(UniProtKB)
|
Alt. Names/Synonyms: OTTMUSP00000003889; WBP-2; Wbp2; WW domain binding protein 2; WW domain-binding protein 2
|
Gene Symbols: Wbp2
|
Molecular weight:
28,032 Da
|
Basal Isoelectric point:
5.94
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|