UBE2E3 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. Belongs to the ubiquitin-conjugating enzyme family. Ubiquitously expressed at low levels. Highly expressed in skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of mouse Ortholog: 2|2 C3
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; nucleotide binding; protein binding; transferase activity; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity
Biological Process:  protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein K63-linked ubiquitination; regulation of growth
Reference #:  P52483 (UniProtKB)
Alt. Names/Synonyms: E2 ubiquitin-conjugating enzyme E3; OTTMUSP00000018105; UB2E3; Ubce4; UbcM2; Ube2e3; Ubiquitin carrier protein E3; ubiquitin-conjugating enzyme 4; Ubiquitin-conjugating enzyme E2 E3; Ubiquitin-conjugating enzyme E2-23 kDa; ubiquitin-conjugating enzyme E2E 3; ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog; ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog (yeast); Ubiquitin-protein ligase E3
Gene Symbols: Ube2e3
Molecular weight: 22,913 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein