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TRIP13
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation. Belongs to the AAA ATPase family. PCH2 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 13 C1|13 40.15 cM |
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Cellular Component:
chromosome; male germ cell nucleus; nucleus
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Molecular Function:
ATP binding; ATP hydrolysis activity; identical protein binding; nucleotide binding; protein binding
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Biological Process:
cell differentiation; double-strand break repair; female meiosis I; male meiosis I; meiotic cell cycle; meiotic recombination checkpoint signaling; mitotic spindle assembly checkpoint signaling; oocyte maturation; oogenesis; reciprocal meiotic recombination; spermatid development; spermatogenesis; synaptonemal complex assembly
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Reference #:
Q3UA06
(UniProtKB)
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Alt. Names/Synonyms: 2410002G23Rik; D13Ertd328; D13Ertd328e; Pachytene checkpoint protein 2 homolog; PCH2; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13; Trip13; TRP13
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Gene Symbols: Trip13
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Molecular weight:
48,377 Da
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Basal Isoelectric point:
5.58
Predict pI for various phosphorylation states
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