TRIM39 E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Belongs to the TRIM/RBCC family. Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of mouse Ortholog: 17|17 B1
Cellular Component:  cytoplasm; cytosol; mitochondrion; nucleus
Molecular Function:  identical protein binding; metal ion binding; transferase activity; ubiquitin protein ligase activity; zinc ion binding
Biological Process:  apoptotic process; mitotic G2 DNA damage checkpoint signaling; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-dependent protein catabolic process; positive regulation of apoptotic signaling pathway; protein stabilization; protein ubiquitination; regulation of cell cycle G1/S phase transition
Reference #:  Q9ESN2 (UniProtKB)
Alt. Names/Synonyms: 1100001D15Rik; E130103K13Rik; E3 ubiquitin-protein ligase TRIM39; KIAA4179; mKIAA4179; RBCC-B30.; RBCC-B30.2; RING finger protein 23; RING-B box-coiled coil-B30.2; RING-B box-coiled-coil-B30.2; RING-type E3 ubiquitin transferase TRIM39; Rnf; Rnf23; Testis-abundant finger protein; Tfp; TRI39; Trim39; tripartite motif protein 39; tripartite motif-containing 39; Tripartite motif-containing protein 39
Gene Symbols: Trim39
Molecular weight: 56,369 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene