TRB3 Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. Note: This description may include information from UniProtKB.
Protein type: CAMK group; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trbl family
Chromosomal Location of Human Ortholog: 2 G3|2 74.83 cM
Cellular Component:  nuclear membrane; nucleolus; nucleus
Molecular Function:  ATP binding; enzyme binding; mitogen-activated protein kinase kinase binding; protein binding; protein kinase activity; protein kinase binding; protein kinase inhibitor activity; transcription corepressor activity; ubiquitin protein ligase binding; ubiquitin-protein transferase regulator activity
Biological Process:  apoptotic process; cellular response to insulin stimulus; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; negative regulation of fat cell differentiation; negative regulation of fatty acid biosynthetic process; negative regulation of protein kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of ubiquitin-protein transferase activity; protein phosphorylation; regulation of autophagy; regulation of glucose transmembrane transport; regulation of MAP kinase activity; response to endoplasmic reticulum stress
Reference #:  Q8K4K2 (UniProtKB)
Alt. Names/Synonyms: Ifl; Ifld2; induced in fatty liver dystrophy 2; Neuronal cell death-inducible putative kinase; Nipk; OTTMUSP00000016895; SINK; SKIP3; Trb; TRB-3; Trb3; Trib3; Tribbles homolog 3; tribbles homolog 3 (Drosophila); tribbles pseudokinase 3
Gene Symbols: Trib3
Molecular weight: 39,023 Da
Basal Isoelectric point: 7.17  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene