TDRD3 Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Histone-binding; RNA-binding; Transcription, coactivator/corepressor; Translation
Chromosomal Location of Human Ortholog: 14|14 E1
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus
Molecular Function:  chromatin binding; methylated histone binding; RNA binding; transcription coactivator activity
Biological Process:  chromatin organization; mRNA processing
Reference #:  Q91W18 (UniProtKB)
Alt. Names/Synonyms: 4732418C03Rik; 6720468N18; Tdrd3; tudor domain containing 3; Tudor domain-containing protein 3
Gene Symbols: Tdrd3
Molecular weight: 82,253 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TDRD3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene