TDO2 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Belongs to the tryptophan 2,3-dioxygenase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.11; Oxidoreductase
Chromosomal Location of Human Ortholog: 3|3 E3
Cellular Component: 
Molecular Function:  amino acid binding; dioxygenase activity; heme binding; identical protein binding; metal ion binding; oxidoreductase activity; oxygen binding; tryptophan 2,3-dioxygenase activity
Biological Process:  oxidation-reduction process; protein homotetramerization; tryptophan catabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; tryptophan metabolic process
Reference #:  P48776 (UniProtKB)
Alt. Names/Synonyms: AA407491; OTTMUSP00000026825; T23O; TDO; tdo variant1; tdo variant2; Tdo2; TO; TRPO; Tryptamin 2,3-dioxygenase; Tryptophan 2,3-dioxygenase; Tryptophan oxygenase; Tryptophan pyrrolase; tryptophan-2,3-dioxygenase; Tryptophanase
Gene Symbols: Tdo2
Molecular weight: 47,756 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
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TDO2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene