SUMO2 Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX. Belongs to the ubiquitin family. SUMO subfamily. Broadly expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin-like modifier
Chromosomal Location of mouse Ortholog: 11|11 E2
Cellular Component:  nucleus; PML body
Molecular Function:  protein tag; retinoid X receptor binding; SUMO transferase activity; transcription corepressor binding; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding
Biological Process:  cellular protein localization; negative regulation of transcription, DNA-templated; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein sumoylation; positive regulation of transcription by RNA polymerase II; protein sumoylation
Reference #:  P61957 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000003569; Sentrin-2; small ubiquitin-like modifier 2; Small ubiquitin-related modifier 2; Smt3; SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 2 (yeast); SMT3 supressor of mif two 3 homolog 2; Smt3A; Smt3b; Smt3h; Smt3h2; SUMO-2; Sumo2; ubiquitin-like protein SMT3A; Ubiquitin-like protein SMT3B
Gene Symbols: Sumo2
Molecular weight: 10,871 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling  |  NF-kB Signaling  |  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene