JDP2 Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. Belongs to the bZIP family. ATF subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12|12 D2
Cellular Component:  nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; protein binding; protein heterodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription corepressor activity
Biological Process:  negative regulation of fat cell differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of histone deacetylation; regulation of histone deacetylation; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  P97875 (UniProtKB)
Alt. Names/Synonyms: Jdp2; Jun dimerization protein 2; Jundm2; Jundp2; TIF
Gene Symbols: Jdp2
Molecular weight: 18,675 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
Select Structure to View Below

JDP2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA