SMARCA4 a core component of multiprotein chromatin-remodeling complexes that regulate transcriptional activation and repression of select genes by ATP-dependent chromatin remodeling (alteration of DNA-nucleosome topology). Is a component of remodeling complexes including Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, WINAC and Brg1. Each complex contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, BAF53A or BAF53B, SMARCC2 and SMARCB1. SWI/SNF complexes are required for mammalian development and are mutated in ~20% of all human primary tumors. Belongs to the neural progenitor-specific and the neuron-specific chromatin remodeling complexes (npBAF and nBAF, respectively). Transcriptional coactivator of nuclear hormone receptors. Colocalizes with ZEB1 in stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. SMARCA4, in consort with ZEB1, represses the transcription of E-cadherin and promotes the epithelial-to-mesenchymal transition (EMT). Required for stem cell maintenance in the mouse intestinal epithelium. Its loss inhibits aberrant Wnt-signaling and prevents tumorigenesis in the mouse small intestine. SMARCA4 mutations are the cause of a familial cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the most aggressive and lethal malignancies occurring in early childhood. Belongs to the SNF2/RAD54 helicase family. The human protein includes 5 isoforms produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 9 A3|9 7.84 cM
Cellular Component:  heterochromatin; nBAF complex; npBAF complex; nuclear chromatin; nuclear euchromatin; nucleus; perichromatin fibrils; SWI/SNF complex
Molecular Function:  androgen receptor binding; ATP binding; ATPase activity; chromatin binding; DNA binding; DNA polymerase binding; DNA-dependent ATPase activity; helicase activity; histone binding; hydrolase activity; hydrolase activity, acting on acid anhydrides; lysine-acetylated histone binding; nucleotide binding; p53 binding; protein binding; protein N-terminus binding; protein-containing complex binding; RNA binding; RNA polymerase I CORE element sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; Tat protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding
Biological Process:  aorta development; aortic smooth muscle cell differentiation; ATP-dependent chromatin remodeling; blastocyst growth; blastocyst hatching; blood vessel development; cell morphogenesis; chromatin organization; chromatin remodeling; coronary vasculature development; definitive erythrocyte differentiation; DNA methylation on cytosine within a CG sequence; embryonic hindlimb morphogenesis; embryonic organ morphogenesis; epidermis morphogenesis; extracellular matrix organization; forebrain development; glial cell fate determination; heart development; heart trabecula formation; hindbrain development; histone H3 acetylation; in utero embryonic development; keratinocyte differentiation; lens fiber cell development; liver development; methylation-dependent chromatin silencing; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nervous system development; neurogenesis; nucleosome assembly; nucleosome disassembly; outflow tract morphogenesis; pharyngeal arch artery morphogenesis; positive regulation by host of viral transcription; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of DNA-binding transcription factor activity; positive regulation of glucose mediated signaling pathway; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; positive regulation of transcription, DNA-templated; positive regulation of Wnt signaling pathway; regulation of cell migration; regulation of transcription, DNA-templated; stem cell population maintenance; vasculogenesis; ventricular septum development
Reference #:  Q3TKT4 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase SMARCA4; BAF190A; Brg1; BRG1-associated factor 190A; HP1-BP72; Protein brahma homolog 1; Smarca4; SMCA4; SNF2-beta; Snf2b; SNF2beta; Snf2l4; SW1/SNF; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1
Gene Symbols: Smarca4
Molecular weight: 181,427 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SMARCA4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA