SMARCA3 an enzyme with both helicase and E3 ubiquitin ligase activities. Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily. Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.6.1.-; EC 3.6.4.-; EC 6.3.2.-; EC; Helicase; Ligase; Nucleolus; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of mouse Ortholog: 3 A2|3 6.15 cM
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  ATP binding; ATPase activity; catalytic activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; helicase activity; hydrolase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; metal ion binding; nucleic acid binding; nucleotide binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transferase activity; ubiquitin protein ligase activity; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  chromatin organization; metabolic process; positive regulation of transcription by RNA polymerase II; protein ubiquitination; regulation of transcription by RNA polymerase II
Reference #:  Q6PCN7 (UniProtKB)
Alt. Names/Synonyms: AF010600; BC057116; Helicase-like transcription factor; helicase-like transcription factor-like protein; Hltf; OTTMUSP00000031817; P11; P113; RING-type E3 ubiquitin transferase HLTF; RUSH; Sma; Smarca3; Snf; Snf2l3; Sucrose nonfermenting protein 2-like 3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; TNF-response element-binding protein; Zbu1
Gene Symbols: Hltf
Molecular weight: 113,317 Da
Basal Isoelectric point: 8.35  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein