SMARCA2 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Belongs to the SNF2/RAD54 helicase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 19 C1|19 21.17 cM
Cellular Component:  intermediate filament cytoskeleton; intracellular membrane-bounded organelle; nBAF complex; npBAF complex; nuclear chromatin; nucleoplasm; nucleus; SWI/SNF complex
Molecular Function:  ATP binding; ATPase activity; chromatin binding; DNA binding; DNA-dependent ATPase activity; helicase activity; histone binding; hydrolase activity; hydrolase activity, acting on acid anhydrides; nucleotide binding; protein binding; transcription coactivator activity; transcription regulatory region DNA binding
Biological Process:  aortic smooth muscle cell differentiation; ATP-dependent chromatin remodeling; chromatin organization; chromatin remodeling; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of transcription, DNA-templated; nervous system development; nucleosome assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated
Reference #:  Q6DIC0 (UniProtKB)
Alt. Names/Synonyms: 2610209L14Rik; ATP-dependent helicase SMARCA2; BAF190B; brahma; BRG1-associated factor 190B; Brm; Probable global transcription activator SNF2L2; Protein brahma homolog; Smarca2; SMCA2; Snf; SNF2-alpha; Snf2a; SNF2alpha; Snf2l2; subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
Gene Symbols: Smarca2
Molecular weight: 180,253 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA