SLCO4A1 Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. Belongs to the organo anion transporter (TC 2.A.60) family. Ubiquitous, with the exception of spleen and leukocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 2|2 H4
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  organic anion transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity
Biological Process:  ion transport; organic anion transport; sodium-independent organic anion transport; thyroid hormone metabolic process; transmembrane transport
Reference #:  Q8K078 (UniProtKB)
Alt. Names/Synonyms: MGC28799; MGC28824; OAT; OATP-E; Oatp4a1; Oatpe; Organic anion-transporting polypeptide E; OTTMUSP00000017537; OTTMUSP00000017538; Slc21; Slc21a12; Slco4a1; SO4A1; Sodium-independent organic anion transporter E; solute carrier family 21 (organic anion transporter), member 12; Solute carrier family 21 member 12; Solute carrier organic anion transporter family member 4A1; solute carrier organic anion transporter family, member 4a1
Gene Symbols: Slco4a1
Molecular weight: 77,669 Da
Basal Isoelectric point: 8.18  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene