|
SLCO4A1
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. Belongs to the organo anion transporter (TC 2.A.60) family. Ubiquitous, with the exception of spleen and leukocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of mouse Ortholog: 2|2 H4 |
|
Cellular Component:
membrane
|
|
Molecular Function:
organic anion transmembrane transporter activity; prostaglandin transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity; transmembrane transporter activity
|
|
Biological Process:
monoatomic ion transport; sodium-independent organic anion transport; thyroid hormone metabolic process; transmembrane transport
|
|
Reference #:
Q8K078
(UniProtKB)
|
|
Alt. Names/Synonyms: MGC28799; MGC28824; OAT; OATP-E; Oatp4a1; Oatpe; Organic anion-transporting polypeptide E; OTTMUSP00000017537; OTTMUSP00000017538; Slc21; Slc21a12; Slco4a1; SO4A1; Sodium-independent organic anion transporter E; solute carrier family 21 (organic anion transporter), member 12; Solute carrier family 21 member 12; Solute carrier organic anion transporter family member 4A1; solute carrier organic anion transporter family, member 4a1
|
|
Gene Symbols: Slco4a1
|
|
Molecular weight:
77,669 Da
|
|
Basal Isoelectric point:
8.18
Predict pI for various phosphorylation states
|
