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SLAMF7
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of proinflammatory cytokines. Isoform 3 does not mediate any NK cell activation. Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Immunoglobulin superfamily; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 1|1 H3 |
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Cellular Component:
external side of plasma membrane; membrane; plasma membrane
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Molecular Function:
identical protein binding; protein binding
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Biological Process:
adaptive immune response; immune system process; innate immune response; regulation of natural killer cell activation; T cell activation
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Reference #:
Q8BHK6
(UniProtKB)
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Alt. Names/Synonyms: 19A; 19A2; 19A24; 4930560D03Rik; CD319; CRACC; CS1; Leukocyte cell-surface antigen; Novel Ly9; SLAF7; SLAM family member 7; Slamf7
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Gene Symbols: Slamf7
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Molecular weight:
37,187 Da
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Basal Isoelectric point:
8.03
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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